What are some video games with female main characters?

My wife likes playing video games, but prefers to play female characters; however, she wants to play games that are centered AROUND the female character, like Tomb Raider or Tenchu perhaps. That is to say, she wouldn't play WoW because you can choose male or female, or rather more specifically because choosing a female has no impact on the plot.
Any suggestions? I'm not having much luck googling.